The 1999 NCAA Division I tournament championship game was played at University of Maryland's Byrd Stadium with an attendance of 24,135. After building a 9-3 lead in the third quarter, the Virginia Cavaliers were able to hold off the Syracuse Orange, the number eight seed, 12-10. It was Virginia's first NCAA title since 1972 and third overall including one pre-NCAA tournament Wingate Trophy. Syracuse was the first number eight seed to make it to the title game.
Virginia's Conor Gill was named the most outstanding player of the tournament — the first freshman ever to win that honor. Other notable players included Virginia's Jay Jalbert, Syracuse's Ryan Powell, and Delaware's lacrosse player of the year, John Grant, Jr., who led the Delaware Blue Hens to a number six national ranking and only their second ever tournament appearance.
| First Round | Quarterfinals | Semifinals | Final | |||||||||||||||
| 8 | Syracuse | 7 | ||||||||||||||||
| Princeton | 5 | |||||||||||||||||
| 1 | Loyola | 12 | ||||||||||||||||
| 8 | Syracuse | 17 | ||||||||||||||||
| 8 | Syracuse | 13 | ||||||||||||||||
| 5 | Georgetown | 10 | ||||||||||||||||
| 4 | Duke | 14 | ||||||||||||||||
| 5 | Georgetown | 17 | ||||||||||||||||
| 5 | Georgetown | 14 | ||||||||||||||||
| Notre Dame | 10 | |||||||||||||||||
| 8 | Syracuse | 10 | ||||||||||||||||
| 3 | Virginia | 12 | ||||||||||||||||
| 6 | Delaware | 12* | ||||||||||||||||
| UMBC | 11 | |||||||||||||||||
| 3 | Virginia | 17 | ||||||||||||||||
| 6 | Delaware | 10 | ||||||||||||||||
| 3 | Virginia | 16 | ||||||||||||||||
| 2 | Johns Hopkins | 11 | ||||||||||||||||
| 2 | Johns Hopkins | 11 | ||||||||||||||||
| 7 | Hofstra | 7 | ||||||||||||||||
| 7 | Hofstra | 15 | ||||||||||||||||
| Navy | 7 | |||||||||||||||||
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